Descriptive cross –sectional study on neonatal sepsis in the Neonatal intensive care unit of Tekur Anbessa Hospital, Addis Ababa , Ethiopia

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Abstract


Background: Neonatal infection accounts for nearly 1.75 million deaths worldwide and the developing countries are responsible for about 1.6 million of these deaths. Not only is there a burden of higher infection rates, but increasing resistance to commonly used antibiotics has become an additional and important problem in these resource poor setups. There are only a few published studies done on neonatal sepsis in Ethiopia, and more than a decade has elapsed since the last one. It is prudent to see if there is any change since then.

Objective: The general objective of this paper is to study about the demography, symptomatology, etiology and sensitivity patterns of Neonatal Sepsis in the NICU of Tekur Anbessa Hospital.

Methodology: This study is a cross-sectional retrospective study which included a population of Neonates with Sepsis clinically suspected and definitive diagnosis made by blood culture within a one year period between Sept.1, 2007 and Aug.31, 2008. Information like Gestational Age, sex, birth weight, the type of infection, their duration of stay, their final outcome, the etiologic bacteria and their sensitivity patterns were recorded. Using the computer program SPSS v16 the study variables were analysed and important associations were evaluated.

Results: There were a total of 578 neonates (280 males and 298 females) suspected of sepsis. Culture positivity rate found was 28.7% from the suspected cases.. Early onset sepsis accounted for 36.7% of confirmed sepsis, 45.8% had Late onset sepsis and the rest 17.5% had Hospital acquired sepsis The risk of infection is found to be higher in premature neonates; OR = 2.92 (1.97

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